Heart failure and COVID-19: A dynamic and changing interaction

by:
Eduardo Chuquiure-Valenzuela

In several COVID-19 cases, acute myocarditis results in focal or global myocardial inflammation, necrosis1. Clinically presents ventricular dysfunction and tachyarrhythmias2-3. Also, may influence in cardiac contractile worsening with a severe impact on Heart Failure (HF).

It is postulated that Heart Failure  risk is mediated by a decrease in myocardial oxygen supply caused by hypoxia and severe respiratory distress. Worsening in myocardial oxygen is exaggerated by sympathetic stimulation.  Myocarditis, myocardial depression, and myocyte necrosis is mediated by an increase in proinflammatory cytokines3-4.

Acute myocardial injury during COVID-19 may be asymptomatic and can be detected only by laboratory markers.  The clinical presentation of COVID-19 is extremely variable. It may be asymptomatic or cause mild symptoms such as fever, dry cough, and fatigue1,2,4,5.  On the other side of the spectrum, a severe pneumonic distress with clinical deterioration and cardiogenic shock may be present.

A frequent cause of hospital admission among cardiac patients is COVID-19 pneumonia6, but the most common cause of hospitalization due to cardiovascular decompensation is HF. Prevalence of HF in COVID-19 patients7,9-12 was dynamic and changing, according to the time of presentation and region (Figure 1).  Bromage et al13 reported a significantly lower hospitalization rate for acute HF during the COVIDÔÇÉ19 pandemic, but hospitalized patients had higher rates of NYHA III or IV symptoms and severe peripheral edema at admission.  Heart Failure patients  may be at increased risk for severe disease and complications associated to COVID-19 and can worsen HF 8.  Mortality was reported, Shi9 et al and Inciardi14 et al described an increment in HF mortality rates (51.2%, 63.2% respectively). Confirming the high risk of HF mortality.

With a higher risk for severe infection, worsening and complications, general recommendation for HF outpatients are social isolation, telemedicine, guideline-directed medical therapy, and self-daily care also protective measures to prevent infection8. Limiting hospital care and admissions based on health systems have been reorganized or reconverted. Reza et al15 and DeFilippis8 et al hypothesizedsevere consequences in socioeconomically disadvantaged populations especially in HF outpatients,  who live in low-middle income countries in which health systems are challenged with limited access to remote care, therapeutics, and may endure disproportionate cardiovascular morbidity and mortality15.

Limitations

Variability in current reports may indicate a different clinical pattern of HF associated with COVID-19 that shows limitations of observational data, inclusion criteria heterogeneity, temporality and geographic biases, residual confounding factors that potentially affect external validity and results may not be generalizable.

Summary

Heart failure in COVID-19 pandemic has a dynamic and changing process

  • Clinical  feature can be broad and assorted.
  • Leading cause of cardiovascular hospitalization is HF
  • HF Increases morbidity and mortality risk especially in LMIC countries.

References

1.- Tavazzi doi:10.1002/ejhf.1828

2.- Shi doi:10.1093/eurheartj/ehaa408

3.- Dong  https://doi.org/10.1016/j.jchf.2020.04.001

4.- Tersalvi Journal of Cardiac Failure Vol. 00 No. 00 2020

5.-Hendren 10.1161/CIRCULATIONAHA.120.047349

6.-Tomasoni  10.1002/ejhf.1871

7.-Chen https://doi.org/10.1136/bmj.m1091

8.- DeFilippis. JACC Heart Fail ; 2020 Jun 02.

9.-Shi doi:10.1001/jamacardio.2020.0950

10.-Mancia www.nejm.org/doi/full/10.1056/NEJMoa2006923

11.-Reynolds DOI: 10.1056/NEJMoa2008975

12.-Richardson doi:10.1001/jama.2020.6775

13.- Bromage https://doi.org/10.1002/ejhf.1925

14.-Inciardi https://doi.org/10.1093/eurheartj/ehaa388

15.- Reza Circ Heart Fail ; 13(5): e007219, 2020 05.

by Eduardo Chuquiure-Valenzuela

Clinical Cardiologist

National Heart Instituto of Mexico

EL-19 Word Heart Federation

Figure 1 Prevalence of Heart Failure in COVID-19 patients

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: